Immunoglobulin-Producing Cells in Blood and Cerebrospinal Fluid during the Course of Aseptic Meningoencephalitis
- 1 June 1983
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 17 (6) , 531-537
- https://doi.org/10.1111/j.1365-3083.1983.tb00821.x
Abstract
The protein A plaque assay was used to quantitate the number of IgG-, IgA-, and IgM-producing cells per 20 × 103 lymphocytes in cerebrospinal fluid (CSF) and peripheral blood (PB) from 23 patients with aseptic meningoencephalitis (AM) in the acute stage 1–10 days after onset (group 1) and during late convalescence after 19–38 days (group II) and in PB from healthy controls. In the acute stage, IgG- and IgM-producing cells were found with significantly higher frequency in both CSF and PB than in the late convalescence. In both patient groups there were more Ig-producing cells in PB than in CSF. The predominant Ig class in PB of AM patients was IgA, just as in healthy individuals. In CSF, IgA- and IgG-producing cells predominated at similar frequencies. In the group I patients, there were positive correlations between numbers of Ig-producing cells of each class and the corresponding CSF Ig index, an indicator of intrathecal Ig synthesis. Since high numbers of Ig-producing cells could be found in CSF that was otherwise normal, enumeration of Ig-producing cells is considered a more sensitive indicator of the immune response intrathecally than measurement of free IgsKeywords
This publication has 10 references indexed in Scilit:
- Immunoglobulin-producing cells in CSF and blood from patients with multiple sclerosis and other inflammatory neurological diseases enumerated by Protein-A plaque assayJournal of Neuroimmunology, 1981
- Viral antibodies in oligoclonal and polyclonal IgG synthesized within the central nervous system over the course of mumps meningitisJournal of Neuroimmunology, 1981
- Immunoglobulins in the cerebrospinal fluid: changes during acute viral encephalitis in mice.The Journal of Immunology, 1981
- Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference valuesScandinavian Journal of Clinical and Laboratory Investigation, 1977
- A plaque assay for all cells secreting Ig of a given type or classEuropean Journal of Immunology, 1976
- Immunoglobulin Synthesis In Vitro by Cerebrospinal Fluid Cells in Patients with Meningoencephalitis of Presumed Viral Origin.Scandinavian Journal of Immunology, 1975
- Immunoglobulins in Multiple Sclerosis and Infections of the Nervous SystemArchives of Neurology, 1971
- Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous systemNeurology, 1970
- The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel FiltrationScandinavian Journal of Clinical and Laboratory Investigation, 1968