Treatment With Human Analog (GlyA21, ArgB31,ArgB32) Insulin Glargine (HOE901) Resolves a Generalized Allergy to Human Insulin in Type 1 Diabetes

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Abstract
In 1985, his first insulin therapy was started. Although he had no history of past illness, including any type of allergy or atopic background, the first subcutaneous injection with pork insulin (semi-lente type) induced allergic reactions, including transient skin rash, itching all over the body, and facial edema. Several days later, injection was restarted once daily with beef insulin (semi-lente type). However, beef insulin also induced generalized allergic reactions. Fortunately, the allergic reactions to beef insulin were far less intense than those to pork insulin. In 1989, the insulin therapy was switched from beef to human insulin. However, the allergic reactions presented yet again. An antihistaminic drug reduced the allergy, but did not eliminate the reactions.