Prenatal testing for inherited immune deficiencies by fetal blood sampling
- 1 April 1982
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 2 (2) , 109-113
- https://doi.org/10.1002/pd.1970020206
Abstract
In an attempt to develop a prenatal diagnosis in [human] fetuses at risk for immunodeficiency, fetal blood sampling was performed under fetoscopy at 18-22 wk of gestation. Normal values were obtained from 35 control fetuses whose blood punctures were undertaken for the diagnosis of hemoglobinopathies. Surface markers and in vitro mitogen-induced proliferation of the fetal lymphocytes were studied by micromethods. Two fetuses at risk for 2 different types of severe combined immunodeficiency were then examined. Their immunological integrity was established, hence avoiding an unjustified termination of pregnancy. This immunological integrity was confirmed after birth.This publication has 13 references indexed in Scilit:
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