Adult severe combined immunodeficiency and sarcoid‐like granulomas with hypersplenism
- 1 January 1978
- journal article
- research article
- Published by Wiley in American Journal of Hematology
- Vol. 5 (1) , 55-62
- https://doi.org/10.1002/ajh.2830050108
Abstract
A patient presented with lymphopenia, anergy, hypogammaglobulinemia and hypersplenism. Histologic examination of the spleen and lymph node revealed noncaseating sarcoid‐like granulomas. Despite a significant rise in circulating lymphocytes after splenectomy there was in vivo and in vitro evidence of B‐ and T‐lymphocyte dysfunction. A histologic picture mimicking sarcoidosis may occur in patients with immune deficiency. The granulomatous proliferation may represent an altered host response to antigen.Keywords
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