Peptide synthesis. Part 4. Solid-phase syntheses of peptides related to gastrin
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 75-82
- https://doi.org/10.1039/p19830000075
Abstract
Details are given of the synthesis of the tetradecapeptide amide [12-leucine]human minigastrin I and its des-1-tryptophan analogue using solid-phase methods based on polar polydimethylacrylamide supports. Exposure to acidic reagents during the synthesis was minimised by use of Nα-fluorenylmethoxycarbonyl-amino-acids and t-butyl-based side-chain protecting groups. High yields of readily purified minigastrin analogues were obtained showing the full biological activity of the natural hormone.This publication has 2 references indexed in Scilit:
- Peptide synthesis. Part 1. Preparation and use of polar supports based on poly(dimethylacrylamide)Journal of the Chemical Society, Perkin Transactions 1, 1981
- Minigastrin: Corrected Structure and SynthesisHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1979