ACUTE-LEUKEMIA ASSOCIATED WITH THE T(4, 11) CHROMOSOME REARRANGEMENT - ULTRASTRUCTURAL AND IMMUNOLOGICAL CHARACTERISTICS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (6) , 1321-1331
Abstract
The acute leukemia associated with the t(4;11) chromosome rearrangement is characterized by relatively consistent clinical features: occurrence primarily in young individuals, hyperleukocytosis and poor response to therapy. Morphological, ultrastructural and immunologic characteristics of the leukemic cells from 10 patients with this type of leukemia are described. The morphological features of the leukemic blasts vary from lymphoid-appearing to monocytic. Ultrastructurally and cytochemically, some of the lymphoid-appearing blasts possess features of myeloid origin. The immunologic phenotype is characteristically E- SIg- CALLA- BA-1- BA-2+ HLA-DR+ and TdT+. Apparently, the t(4;11)-associated acute leukemia represents a proliferation of an early myeloid progenitor cell.

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