Beta-cell function improved by supplementing basal insulin secretion in mild diabetes.
- 22 May 1976
- Vol. 1 (6020) , 1252-1254
- https://doi.org/10.1136/bmj.1.6020.1252
Abstract
Insulin supplements, predominantly as a constant basal fish insulin infusion, were given to patients with mild diabetes to reduce the overnight fasting glucose level to normal. The basal plasma human insulin levels were reduced to subnormal levels by the infusion, and the insulin response to intravenous glucose was enhanced. The beta-cell in diabetes seems to be in a vicious circle in which an impaired insulin response to glucose produces hyperglycaemia, which stresses beta-cell function, making it more inefficient. A constant basal insulin supplement to induce basal normoglycaemia may benefit beta-cell function in diabetes.Keywords
This publication has 8 references indexed in Scilit:
- Early Response of Plasma Insulin to Small Doses of Intravenous Glucose: Effect of ObesityJournal of Clinical Endocrinology & Metabolism, 1974
- SUPPRESSION OF INSULIN RELEASE BY FISH-INSULIN-INDUCED HYPOGLYCÆMIA WITH REFERENCE TO THE DIAGNOSIS OF INSULINOMASThe Lancet, 1973
- Effect of Control of Hyperglycemia on Plasma Insulin Responses to Various Stimuli in Newly Diagnosed Ketosis-Prone Diabetic PatientsJournal of Clinical Endocrinology & Metabolism, 1972
- A SENSITIVE, PRECISE RADIOIMMUNOASSAY OF SERUM INSULIN RELYING ON CHARCOAL SEPARATION OF BOUND AND FREE HORMONE MOIETIESActa Endocrinologica, 1972
- Acute and steady-state insulin responses to glucose in nonobese diabetic subjectsJournal of Clinical Investigation, 1972
- Relationships Between Intravenous Glucose Loads, Insulin Responses and Glucose Disappearance Rate1Journal of Clinical Endocrinology & Metabolism, 1971
- Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetesJournal of Clinical Investigation, 1970
- Effect of bonito insulin on endogenous insulin secretion in dogsAmerican Journal of Physiology-Legacy Content, 1970