Effect of Gluten on Glucose Absorption from the Small Intestine in Experimentally Induced Malabsorption in Rats

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Abstract
The influence of gluten (exposure and withdrawal from the diet) on glucose absorption from the Triparanol-damaged small intestine of the rat was studied and compared with the absorption of normal controls. The following findings were obtained: (1) In normal rats, no effect of gluten on glucose absorption could be demonstrated; (2) Triparanol-induced malabsorption was measurably improved by a gluten-free diet, and this improvement was statistically significant; (3) Renewed exposure to gluten leads to renewed reduction of glucose absorption from Triparanol-damaged small intestine. The findings are discussed with respect to the specificity of the gluten effect in gluten-induced enteropathy, i.e., coeliac disease, and also with reference to their therapeutical aspects in the management of malabsorption syndromes in general.

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