The effects of salicylate and adrenocortical preparations added in vitro upon the glycogen content of liver slices

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Abstract
The effects of the addition of salicylate, adrenocortical extract, cortisone and hydrocortisone on the glycogen content of rat-liver slices incubated in buffered physiological salt solutions were investigated. Salicylate caused a significant increase in the glycogen disappearance in liver slices incubated in a medium containing a high concentration of K and no Na, but not in a medium containing a high proportion of Na. Adreno-cortical extract (Eschatin, free from preservative) but not cortisone or hydrocortisone, produced a significant decrease in the glycogen disappearance and this effect was inhibited by the presence of salicylate. The implications of these effects are discussed.