Effect of selenium compounds on the permeability of rat small intestine to mercury compounds.

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Abstract
The effect of Se compounds on the transport of methylmercury (MMC) and HgCl2 was studied circulating perfusion experiments in an improved in vitro apparatus. When the initial Hg content in the inner solution was 0.5 mM, promotion of Hg transport was observed with addition of 0.01 mM selenite. MMC transport increased greatly with addition of increasing amounts of selenite but HgCl2 transport decreased. When selenite was added to the inner solution containing MMC, its increasing effect on Hg transport was weaker than that of selenite. Transport of HgCl2 was slightly increased by the addition of selenate. Accumulation of Hg in the intestine was hardly changed with increasing addition of selenite or selenate in the case of MMC but increased in the case of HgCl2. Accumulation of Se in the intestine was higher with selenite than selenate. These observations may be closely related to the mechanisms of absorption, distribution and toxicity of Hg compounds in vivo in the presence of Se compounds.

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