Failure of anticholinergic drugs to antagonize the increase in dopamine seen after gammahydroxybutyric acid and axotomy
- 1 March 1979
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 44 (1-2) , 137-143
- https://doi.org/10.1007/bf01252707
Abstract
The increase in dopamine (DA) seen either 30 or 90 min after injection of gammahydroxybutyric acid or 90 min after axotomy of the nigrostriatal DA-fibers was not affected by i.p. injections of either atropine sulfate or atropine methyl nitrate or benztropine. These increases in DA are most probably due to feedback-mechanisms which do not involve cholinergic neurons.This publication has 18 references indexed in Scilit:
- Increase in the turnover of brain dopamine by stimulation of muscarinic receptors outside the dopamine nerve terminalsJournal of Pharmacy and Pharmacology, 1977
- Absence of a ‘cholinergic link’ in the apomorphine-induced feedback inhibition of dopamine synthesis in rat striatumEuropean Journal of Pharmacology, 1976
- Effect of oxotremorine on homovanillic acid concentration in the striatum of the ratEuropean Journal of Pharmacology, 1974
- Dopamine turnover in the corpus striatum and the limbic system after treatment with neuroleptic and anti-acetylcholine drugsJournal of Pharmacy and Pharmacology, 1972
- Interaction between cholinergic and catecholaminergic neurones in rat brainBrain Research, 1972
- Early and selective increase in brain dopamine levels after axotomyCellular and Molecular Life Sciences, 1972
- Influences of cholinergic mechanisms on the function and turnover of brain dopamineJournal of Pharmacy and Pharmacology, 1971
- Adrenergic MechanismsAnnual Review of Pharmacology, 1969
- A Quantitative Study on the Nigro‐Neostriatal Dopamine Neuron System in the RatActa Physiologica Scandinavica, 1966
- Relevance of drug-induced extrapyramidal reactions to behavioral changes during neuroleptic treatment. II. Combined treatment with trifluoperazine-amobarbitalComprehensive Psychiatry, 1962