High Throughput Analysis and Purification in Support of Automated Parallel Synthesis
- 1 January 1997
- journal article
- Published by Springer Nature in Molecular Diversity
- Vol. 3 (1) , 61-70
- https://doi.org/10.1023/a:1009636725336
Abstract
Rapid reverse-phase analytical and preparative HPLC methods havebeen developed for application to parallel synthesis libraries.Gradient methods, short columns, and high flow rates allowanalysis of over 300 compounds per day on a single system, orpurification of up to 200 compounds per day on a singlepreparative system. Hardware and software modifications allowcontinuous unattended use for maximum efficiency and throughput.Keywords
This publication has 8 references indexed in Scilit:
- Encoding methods for combinatorial chemistry.Current Opinion in Chemical Biology, 1997
- Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine TagsJournal of Medicinal Chemistry, 1996
- Synthesis and Applications of Small Molecule LibrariesChemical Reviews, 1996
- Two New Criteria for Choosing Sample Size in Combinatorial ChemistryJournal of Medicinal Chemistry, 1996
- Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial LibrariesJournal of Medicinal Chemistry, 1994
- Complex synthetic chemical libraries indexed with molecular tags.Proceedings of the National Academy of Sciences, 1993
- A new type of synthetic peptide library for identifying ligand-binding activityNature, 1991
- Generation and use of synthetic peptide combinatorial libraries for basic research and drug discoveryNature, 1991