Plasma protein binding of 7-hydroxy-Δ1-tetrahydrocannabinol: an active Δ1-tetrahydrocannabinol metabolite
- 1 June 1973
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 25 (6) , 453-457
- https://doi.org/10.1111/j.2042-7158.1973.tb09132.x
Abstract
7-Hydroxy-Δ1-tetrahydrocannabinol, which is a pharmacologically and psychologically active metabolite of Δ1-tetrahydrocannabinol in man, has been shown by equilibrium dialysis and ultrafiltration to be bound 94–99% to plasma proteins. Further experiments, using the [14C]labelled compound, with agarose and Polyacrylamide gel electrophoresis and ultracentrifugation suggest that albumin, α1-lipoprotein and, to a minor degree, also β-lipoprotein are involved in the protein binding of 7-hydroxy-Δ1-tetrahydrocannabinol in blood plasma.Keywords
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