Ultrastructural changes in neutrophils treated with staphylococcal alpha toxin

Publisher Website
Google Scholar
Abstract
Purified alpha toxin was cytotoxic to rabbit neutrophils as revealed by electron microscopy. Cells treated with alpha toxin showed aggregation of glycogen granules, extensive degranulation, and loss of cytoplasmic ground substance. Vesicles were present within the cytoplasm and outside the cells. The nuclear lobes were round and showed chromatin dissolution. Degranulation of the cell resulted in the formation of vesicles. These ultrastructural changes, except the nuclear changes, were similar to those of leucocytes treated with P-V leucocidin.

This publication has 0 references indexed in Scilit: