Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses
- 8 October 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 286 (5438) , 300-303
- https://doi.org/10.1126/science.286.5438.300
Abstract
The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.Keywords
This publication has 47 references indexed in Scilit:
- The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid TissuesImmunity, 1998
- Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic RegionPublished by Elsevier ,1996
- Affinity maturation without germinal centres in lymphotoxin-α-deficient miceNature, 1996
- A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40FEBS Letters, 1995
- Mice deficient for the CD40 ligandPublished by Elsevier ,1994
- A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorCell, 1994
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.The Journal of Experimental Medicine, 1992
- Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40Science, 1991
- B cell activation and the establishment of Epstein-Barr virus latency.The Journal of Experimental Medicine, 1988
- An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cellsCell, 1985