Effect of Thyroxine on Folic Acid Metabolism

Abstract
Summary The feeding of iodinated casein as a source of thyroxine-like activity increased excretion of formiminoglutamic acid and formate on diets containing folic acid and vitamin B12. Large doses of folate given I.P. produced a partial reduction in FIGLU and formate excretion. Supplementation with 0.2% methionine produced a large and rapid decrease in both FIGLU and formate excretion even when iodinated casein was present in the diet.