Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors
- 1 January 2000
- book chapter
- Published by Springer Nature
- Vol. 54, 59-119
- https://doi.org/10.1007/978-3-0348-8391-7_3
Abstract
An overview is presented on progress made in the research on neuronal transporters of serotonin, dopamine and norepinephrine in the central nervous system. Tools developed by molecular biology, such as expression of cloned transporters, their mutants and chimera in non-neuronal cells offered the opportunity to study the putative domains for binding of substrates and uptake inhibitors and discover factors in the regulation of the transporter function. The study of the distribution of monoamine transporters in human brain became possible by the development of selective radiolabelled transport inhibitors. The relationships between the chemical structure of the uptake inhibitors and the affinity for the monoamine transporters is reported, and the (potential) therapeutic applications of the compounds are discussed.Keywords
This publication has 104 references indexed in Scilit:
- N-Linked Oligosaccharides Are Required for Cell Surface Expression of the Norepinephrine Transporter but Do Not Influence Substrate or Inhibitor RecognitionJournal of Neurochemistry, 2002
- Heterogeneity of Antidepressant Binding Sites on the Recombinant Rat Serotonin Transporter SERT1Biochemistry, 1995
- Prozac (fluoxetine, lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: Twenty years since its first publicationLife Sciences, 1995
- Novel halogenated analogs of tomoxetine that are potent and selective inhibitors of norepinephrine uptake in brainNeurochemistry International, 1995
- Expression of Serotonin Transporter Messenger RNA in the Human BrainJournal of Neurochemistry, 1994
- Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporterFEBS Letters, 1994
- Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomesLife Sciences, 1993
- Isolation of a cDNA encoding the human brain serotonin transporterJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1993
- Isolation of cDNAs encoding a novel member of the neurotransmitter transporter gene familyFEBS Letters, 1991
- Cloning and functional characterization of a cocaine‐sensitive dopamine transporterFEBS Letters, 1991