Cell Membrane Enzymes II..

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Abstract
The distribution of 2 cell membrane enzymes, alkaline phosphatase and alkaline phosphodiesterase I [EC 3.1.4.], was studied in normal and leukemic human lymphocytes. No reduction in the level of activity of either enzyme was found in the chronic or acute B[bone marrow-derived]- and T[thymus-derived]-cell leukemias. Alkaline phosphatase activity was elevated in the lymphocytes from T-CLL [chronic lymphocytic leukemia], cord blood and tonsils and the blast cells from null-ALL [acute lymphocytic leukemia]. Alkaline phosphodiesterase was elevated in lymphocytes from cord blood and tonsils and blast cells from null-ALL. As findings in null-ALL were based on only 2 cases, they need confirmation in a larger series. The significance of these results is discussed in relation to current theories of maturation and differentiation in lymphoproliferative disorders.