Untersuchungen über die Auslösung der viskösen Metamorphose der menschlichen Blutplättchen durch Immunkomplexe

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Abstract
Viscous metamorphosis can be induced in human blood platelets by the addition of heat-aggregated human gammaglobulin. Dense aggregates of platelets are formed which will show active contraction comparable to thrombin-induced clot retraction. Treatment at pH 4 abolishes this property of the aggregated gammaglobulins together with their ability to activate the complement system. Commercial preparations of gammaglobulin, although capable of activating complement, remain without effect on blood platelets, most likely because they are not adequately fixed by the cells. Addition of complement proved unnecessary, and it must be concluded either that human platelets are already loaded with the necessary components of the complement system, or that another mechanism, different from the activation of the entire complement system is involved in this reaction.

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