Hydrocyanation of some α,β-unsaturated ketones, and the synthesis of some unusual isoxazoles
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1153-1162
- https://doi.org/10.1039/p19950001153
Abstract
β-Cyano-α-methylcycloalkanones are regiospecifically nitrosated at the α-position by pentyl nitrite in methanolic sodium methoxide to give fused isoxazolo-lactams via a pathway probably involving sequential cycloalkanone cleavage, isoxazole formation and lactamisation. The chemistry of some new compounds derived from the hydrocyanation products of (–)-carvone is described.Keywords
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