Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5
- 1 December 1995
- journal article
- Published by Springer Nature in Human Genetics
- Vol. 96 (6) , 671-673
- https://doi.org/10.1007/bf00210297
Abstract
Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. We have mapped the gene encoding GDNF by two independent methods: using a cell hybrid panel and by fluorescent in situ hybridisation. We find GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3Keywords
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