A Quantitative Study of the Effect of Vagotomy on Gastric Secretion in the Dog.

Publisher Website
Google Scholar
Abstract
The authors report 12 dogs with pouches of the entire stomach constructed with intact vagus innerva-tion. Quantitative daily collections of gastric juice were made and, in addition, the secretory responses to a test meal, histamine, and intraven. insulin were detd. Transthoracic vagotomy was performed in 9 animals and the studies repeated. Vagotomy reduced the 24 hr. HCl output from 47% to 92%, averaging 77%. Peptic power was reduced in most cases. Vagotomy caused a marked decrease in secretion to histamine stimulation, and the secretory response to insulin hypoglycemia was abolished. Secretion is usually high in these animals in the fasting state, and food-taking causes a profound inhibition lasting 3-7 hrs. Before vagotomy, this is preceded by a brief augmentation. Sectioning the right or left vagus had no effect on secretion. 3 animals died of perforation or hemorrhage of an ulcer in the pouch.

This publication has 2 references indexed in Scilit: