THE EFFECTS OF HYPERTHERMIA AND HYPOTHERMIA ON CERVICAL LYMPH FLOW

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Abstract
Nine dogs and 2 cats, anesthetized and curarized, were subjected to a high environmental temp. (40 to 45[degree]C.) at an avg. relative humidity of 11%. The hyperthermia thus produced caused marked circulatory changes culminating in circulatory collapse and death at 45.3 to 45.7[degree]C. Cervical lymph flow increased and protein % decreased at 2 critical body temp. levels. The first rise, which amounted to 1.4 to 4.5 times the control values and which occurred at a body temp. of 38.3 to 41.1[degree]C, was due to an increase in the rate of capillary filtration caused by peripheral hyperemia. The 2d increase in cervical lymph flow, amounting to 3 to 18 times the normal, appeared at a temp. of 41.9 to 43.5[degree]C, was coincident with the beginning of circulatory collapse, and was caused by a tremendous increase in capillary filtration resulting from a high venous pressure and from capillary stasis and anoxemia leading to injury to the capillary endothelium. Cervical lymph flow in 3 dogs subjected to low environmental temps. (10[degree]C. minimum) failed to be significantly altered when the body temp. was reduced to a minimum value of 25.6[degree]C. With the exception of a decreased heart rate, circulatory changes were not pronounced at this degree of hypothermia. Thoracic duct flow was so variable that no conclusions could be drawn as to the possible influence of changes in body temp. on its production.

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