Electron Capture Determination of Propoxyphene from Human Plasma

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Abstract
A procedure for the determination of propoxyphene (α-d-dimethylamino-1, 2 -diphenyl-3 -methyl-2 -propionoxybutane) in plasma is reported. The method is based on the electron capture characteristics of propoxyphene. The plasma is rendered basic to generate the free amine and extracted with ether. The extract is analyzed by gas chromatography using a 4 foot OV-225 column. An internal standard of imipramine hydrochloride is used to quantitate the propoxyphene. This internal standard is carried through the entire procedure. The ratio of the peak heights of propoxyphene to imipramine is compared to ratios obtained from standards placed in plasma and treated in the same manner as the samples. Six subjects were given propoxyphene at different time intervals, and the data are presented concerning these subjects.

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