The use of nonsteroidal anti-inflammatory agents

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Abstract
The nonsteroidal anti-inflammatory agents available for use in the USA include salicylates, indomethacin, phenylbutazone and oxyphenbutazone. The release of ibuprofen (Motrin) in 1974 and of naproxen (Naprosyn), fenoprofen calcium (Nalfon), and tolmetin (Tolectin) in 1975 brought a new era of anti-inflammatory drugs. These drugs are primarily for the treatment of adult rheumatoid arthritis, although with broader experience these agents are being sanctioned for use in other musculoskeletal disorders. With the exception of tolmetin, these agents are all phenylalkanoic acids. In addition to the agents available for use in the USA, a considerable number of new agents are under active investigation, and some are in use in other countries. These drugs [including Sulindac, Ketoprofen and Meclofenamate sodium] are discussed. Which drug to use first in a given inflammatory disorder has become a problem with the expanded spectrum of agents so comparable in potency. Physicians look for effective agents with few side effects that are easily reversible if they occur. Additional qualifications for new agents include convenience of use in a wide segment of the population for prolonged periods. Most of the new agents are about as effective as aspirin and often better tolerated in short-term studies.

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