Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis
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Open Access
- 7 February 2007
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 297 (5) , 499-508
- https://doi.org/10.1001/jama.297.5.499
Abstract
A large body of evidence supports a central role for lowering levels of low-density lipoprotein cholesterol (LDL-C) in the prevention of atherosclerotic cardiovascular disease. Randomized controlled trials have established that statin-mediated reductions in LDL-C have a favorable effect on the incidence of cardiovascular events.1-6 As a result, LDL-C lowering has become an integral component of therapeutic strategies in the prevention of cardiovascular disease.7 In particular, the use of statins has become widespread.Keywords
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