DIRECT BLOCKADE OF ANTIGEN-REACTIVE LYMPHOCYTES-B BY IMMUNE-COMPLEXES - OFF SIGNAL FOR PRECURSORS OF IGM-PRODUCING CELLS PROVIDED BY LINKAGE OF ANTIGEN-RECEPTORS AND FC-RECEPTORS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 35  (1) , 151-157
Abstract
Antigen-antibody complexes efficiently inhibit the induction of antibody formation. Using Mishell-Dutton cultures [mouse spleen cells] demonstrated that neither T [thymus derived] cells nor their products are required for this inhibition of Ig[immunoglobulin]M PFC [plaque forming cell] formation. The blockade is at the level of B [bone marrow derived] cells and cannot be overcome by LPS [lipopolysaccharide, Salmonella typhi] or TRF [thymus replacing factor]. Cross-linking of antigen- and Fc-receptors by antigen-antibody complexes is probably a blocking signal for B cells.