METABOLIC STUDIES WITH A STEROID ISOLATED FROM THE URINE OF PATIENTS WITH “SALT-LOSING” CONGENITAL ADRENAL HYPERPLASIA*

1 May 1960

journal article
research article
Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism

Vol. 20 (5) , 729-734
https://doi.org/10.1210/jcem-20-5-729

Abstract

3/3,16a-Dihydroxy-allopregnan-20-one, isolated from the urine of patients with "salt-losing" virilizing adrenal hyperplasia, has been reported to induce sodium excretion in rats. Administration of this compound to 5 human subjects (with and without adrenocortical disease) in dosages up to 400 mg. per day failed to modify electrolyte excretion.

Keywords

ADRENAL GLANDS/ABNORMALITIES
ELECTROLYTES/URINE
STEROIDS/PHARMACOLOGY

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