Local Anesthesia

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Abstract
LOCAL anesthesia is defined as a loss of feeling or sensation that is confined to a circumscribed area of the body. This loss of sensation most commonly results from an inhibition of the conduction process in peripheral nervous tissue. Nerve conduction can be altered by many different means – e.g., mechanical trauma, low temperature, anoxia and a variety of chemical irritants such as alcohol or phenol. In clinical practice pharmacologic agents usually employed produce a transient and completely reversible state of anesthesia in the area where loss of sensation is desired.Local-anesthetic agents differ considerably from most other classes of . . .