Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis
Open Access
- 1 August 2002
- journal article
- other
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 61 (8) , 726-729
- https://doi.org/10.1136/ard.61.8.726
Abstract
Objective: To measure serum interleukin 18 (IL18) and IL18 binding protein (IL18BP) levels in patients with inflammatory arthropathies, and to identify associations with disease status and the response to treatment. Methods: Serum samples were obtained before and after methotrexate treatment from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) attending an early arthritis clinic. IL18 and IL18BP were measured by enzyme linked immunosorbent assay (ELISA). Results: Sixty patients with RA and 13 with PsA were evaluated. Serum IL18 levels were significantly higher in RA than in PsA (pConclusion: Raised serum levels of IL18 are consistent with a pathophysiological role in RA. However, in this study measurement of circulating IL18 and IL18BP did not correlate significantly with clinical measures of disease activity or the response to treatment in patients with early RA.Keywords
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