Competition of Antigens as Influenced by Spacing of Heterologous Antigen Injections.

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Abstract
Antibody responses of chickens to single, simultaneous, and spaced injections of bovine serum albumin (BSA) and human gamma globulin (HGG) at a dosage level of 40 mg/kg body weight are described. Following simultaneous injection of BSA and HGG the antibody responses to both antigens approximate those of their respective controls. When the injection of HGG was withheld until 24 hours after that of BSA the response to BSA was significantly reduced. Antibody responses to BSA and HGG in animals in which injection of HGG was delayed for 48 hours approximate the responses of their respective controls. It appears that the character of the antibody response to simultaneous injections of BSA and HGG is regulated by the parameters of dosage level and timing of injections.
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