Cerebellar cAMP levels following acute and chronic morphine administration
- 1 February 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 55 (1) , 117-120
- https://doi.org/10.1139/y77-017
Abstract
Acute administration of morphine sulfate at 20 mg/kg decreased mouse cerebellar adenosine 3′,5′-cyclic phosphate (cAMP) levels while not affecting cAMP phosphodiesterase (EC 3.1.4.17). The cAMP levels and cAMP phosphodiesterase activities were not affected by chronic treatment. However, cAMP levels increased during abrupt withdrawal both with and without naloxone precipitation, with cAMP phosphodiesterase activities being correspondingly decreased. Propanolol prevented the cAMP increase during abrupt withdrawal.This publication has 2 references indexed in Scilit:
- ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*Annals of the New York Academy of Sciences, 1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951