Reproducibility, Construct Validity, and Responsiveness of the “How Are You?” (HAY), a Self-Report Quality of Life Questionnaire for Children with Asthma

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Abstract
This study assesses the reproducibility, construct validity, and responsiveness of a new self-report quality of life questionnaire, the “How Are You?” (HAY), for 8-12-year-old children with asthma, which contains both a generic and a disease-specific part. Two hundred twenty-eight children with asthma completed the HAY and the Child Attitude Toward Illness Scale (CATIS), while their parents monitored the actual asthma status; 80 children were measured three times in order to assess reproducibility and responsiveness; 296 healthy children completed the generic section of the HAY. Significant differences were found between children with asthma and healthy children, and among asthmatic children differing in actual asthma status. Reproducibility was adequate and supportive evidence was found for construct validity. Responsiveness was demonstrated by significant score changes for most dimensions in clinically changed children. The HAY seems useful for both discriminative and evaluative research in children with asthma.