Novel Disaccharides Containing 3-Deoxy-D-Manno-2-Octulosonic Acid (KDO) and Lipid a Subunit Analogs
- 1 December 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 6 (4) , 691-696
- https://doi.org/10.1080/07328308708058898
Abstract
3-Deoxy-D-manno-2-octulosonic acid (KDO)1 is a prominent constituent of bacterial lipopolysaccharides (LPS),2 and recently it has been demonstrated 3,4 that the KDO part in the core region of LPS is α-ketosidically linked to 0-6′ of the o-glucosamine-disaccharide backbone of lipid A. Although the portion, including KDO, has been suggested5,6 to be necessary for expression of antitumor and interleukin 1 (IL 1)-induction activities of LPS, the disticnt biological roles of KDO in LPS are still obscure.Keywords
This publication has 21 references indexed in Scilit:
- Synthesis of nonreducing-sugar subunit analogs of bacterial lipid a carrying an amide-group (3R)-3-acyloxytetradecanoyl groupCarbohydrate Research, 1987
- Synthesis of the optically active 4-O-phosphono-d-glucosamine derivatives related to the nonreducing-sugar subunit of bacterial lipid ACarbohydrate Research, 1987
- Synthesis of 1,5-Anhydro- 2-deoxy- 4-O-phosphono-3-O-tetradecanoyl-2-[(3R)- and (3S)-3-Tetradecanoyloxytetradecanamido]-D-glucitol (GLA-40) Related to Bacterial Lipid AJournal of Carbohydrate Chemistry, 1986
- Synthesis of 2-deoxy-4-O-phosphono-3-O-tetradecanoyl-2-[(3R- and (3S)-3-tetradecanoyloxytetradecanamido]-d-glucose: a diastereoisomeric pair of 4-O-phosphono-d-glucosamine derivatives (GLA-27) related to bacterial lipid ACarbohydrate Research, 1986
- Structure of de-o-acylated lipopolysaccharide from theTetrahedron Letters, 1985
- Molecular requirement for interleukin 1 induction by lipopolysaccharide‐stimulated human monocytes: Involvement of the heptosyl‐2‐keto 3‐deoxyoctulosonate regionEuropean Journal of Immunology, 1985
- Synthesis of biologically active, novel monosaccharide analogs of lipid A.Agricultural and Biological Chemistry, 1984
- Zur struktur der 3-desoxyoctulosonsäure- (KDO-) region des lipopolysaccharids von Re 595Tetrahedron Letters, 1984
- The Chemistry and Biological Significance of 3-Deoxy-d-manno-2-Octulosonic Acid (KDO)Published by Elsevier ,1981
- Regions of the Lipopolysaccharide of Pseudomonas aeruginosa Essential for Antitumor and Interferon‐Inducing ActivitiesEuropean Journal of Biochemistry, 1979