THE OCCURRENCE OF PEPTIC ULCERATION IN PATIENTS WITH PARKINSONISM

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Abstract
In a series of 250 patients with Parkinsonism, 30 (12%) had a verified gastric (7), or duodenal (23) ulcer. Twenty four of the 30 patients (80%) had the ulcer verified before the onset of Parkinsonism. Nine patients in a control group of comparable age, had a verified gastric (3), or duodenal (6) ulcer. The symptoms of Parkinsonism began at a significantly earlier age when the patient had had a preceding ulcer. Patients in the control group had a slight but not significantly increased incidence of ulceration in comparison with the incidence in patients having the diseases concurrently. The action of specific antiParkinson drugs would seem to have, at least to some extent, a protective action against ulcerogenesis. The relationship between Parkinson''s disease and gastroduodenal ulceration is probably a central one. Ulcerogenesis may occur as the result of changes produced by the establishment and evolution of the brain lesion of Parkinsonism, during the preclinical phase of the illness.

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