Influence of the Parasympathetic Nerves and Their Relation to the Action of Atropine in the Ileum and Colon of the Dog

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Abstract
Responses may be elicited throughout the lower bowel of dogs by stimulation of either vagal or pelvic nerves. Atropine sulfate and tetra-ethylammonium bromide depressed but did not abolish these responses. Extrinsic denervation of jejunal Thiry-Vella loops sensitized them to these drugs. Vagotomy and pelvic para-sympathectomy in 8 chronic dogs did not alter motility patterns in the terminal ileum, proximal, or distal colon, but did sensitize the lower bowel to atropine. Such denervation increased the duration of atropine response at all 3 levels of the lower bowel; when the 2 denervations were combined, the increase exceeded 100%.