Cellular Source of Interferon Induced in Human Peripheral Blood Mononuclear Leukocytes by Mumps Virus or by Tumour Cells Persistently Infected with Mumps Virus

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Abstract
Human leukocyte interferon (IFN-.alpha.) was induced in cultures of human peripheral blood mononuclear leukocytes (PBML) from seropositive healthy donors infected by mumps virus or by a human lung carcinoma cell line (Pc-10) persistently infected with mumps virus (Pc-10/MpV). Adherent cells (macrophages, M.vphi.); non-T, non-B cells; and B cells all produced IFN in response to mumps virus or Pc-10/MpV cells. The non-T, non-B cells co-cultured with Pc-10/MpV cells produced high-titer IFN. T cells did not produce any antiviral factors even in the presence of M.vphi.. T cells activated with phytohemagglutinin, concanavalin A or treated with UV-irradiated mumps virus, or Pc-10/MpV cells pretreated with mitomycin C did not produce any antiviral factors in response to mumps virus or Pc-10/MpV cells.