Linking lipids, Alzheimer's and LXRs?
- 1 January 2004
- journal article
- Published by SAGE Publications in Nuclear Receptor Signaling
- Vol. 2 (1) , e001
- https://doi.org/10.1621/nrs.02001
Abstract
Deposition of the β-amyloid (Aβ) peptide is thought to underlie development of Alzheimer's disease (AD). This pathological linkage has spurred considerable interest in therapeutic strategies to reduce Aβ production. It is becoming increasingly clear that altered cholesterol homeostasis can modulate Aβ production and/or accumulation. In this review, we discuss the molecular pathology of AD, the cholesterol connection and recent data suggesting that the oxysterol receptor, liver X receptor LXR (NR1H2 and NR1H3), may modulate these events.Keywords
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