Cutaneous Nerve Lesions in Prurigo Nodularis. Electron Microscopic Study of Two Patients
- 1 June 1976
- journal article
- research article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 3 (3) , 125-132
- https://doi.org/10.1111/j.1600-0560.1976.tb01103.x
Abstract
Skin biopsies from 2 patients with prurigo nodularis were studied by EM. Lesions were found in the cutaneous myelinated and unmyelinated nerves. Schwann-cell cytoplasm showed large, irregular, membrane-bound, electron-lucent vacuoles. Unmyelinated axons were distended and devoid of neurotubules and neurofilaments. Myelinated nerves showed various degrees of demyelination. Onion-bulb formations with a centrally located myelinated fiber were also observed and numerous mast cells were found in the cellular infiltrate. This indicated the presence of a chronic peripheral neuropathy, whose etiology remains to be determined.This publication has 4 references indexed in Scilit:
- Prurigo nodularis. Histological and electron microscopical studyArchives of Dermatology, 1975
- Onion Bulb NeuropathiesArchives of Neurology, 1972
- The Role of Schwann Cells in the Formation of “Onion Bulbs” Found in Chronic Neuropathies***†Journal of Neuropathology and Experimental Neurology, 1967
- Neurohistological Changes in Prurigo NodularisArchives of Dermatology, 1964