CAPTOPRIL AND THE MAINTENANCE OF BLOOD PRESSURE AFTER SINOAORTIC DENERVATION IN THE RABBIT

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Abstract
At a dose of 1 mg/kg intravenously, captopril lowered blood pressure in conscious rabbits, that had undergone denervation of sinoaortic baroreceptors, but had no effect on heart rate. In sham‐operated controls, this dose caused only an increase in heart rate. In the same experiments, captopril caused a substantial inhibition of plasma angiotensin converting enzyme (CE) activity of rapid onset and gradual decline over 2 to 3 h. The time course of recovery of blood pressure and plasma CE activity were similar. Saralasin, by intravenous infusion, lowered blood pressure in sinoaortic rabbits but to a smaller extent than captopril. The fall in blood pressure observed after captopril is not dependent on the integrity of baroreceptor afferents.