Antineoplastic Agents, 88. Pimelea prostrata

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Abstract
The aerial portion of P. prostrata (Thymelaeaceae) collected in New Zealand was evaluated as a souce of substances that inhibit growth of the murine P-388 lymphocytic leukemia (PS). Simplexin and Pimelea factor P2 (2) strongly inhibited growth (ED50 [mean effective dose] 5 .times. 10-3 and 8 .times. 10-4 .mu.g/ml, respectively) of the PS in vitro cell line. The cyclic orthoester (2) also inhibited growth (T/C 132 at 20 .mu.g/kg) of the PS in vivo system. Detailed 1H-NMR (at 400 MHz) and 13C-NMR studies combined with fast atom bombardment mass spectral evidence were used to confirm the structural assignments.

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