A modification of a method for the evaluation of topical anaesthesia in the earthworm
- 1 July 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 19 (7) , 456-459
- https://doi.org/10.1111/j.2042-7158.1967.tb08109.x
Abstract
The method of Block, Potts & Finney (1964) for the evaluation of local anaesthetic activity using the response of the earthworm tail to hydrochloric acid has been found to give false negative results with control solutions. This was because the acid progressively damaged and thus desensitized the tail. This has been overcome by arranging the test so that no tail is immersed in the acid more than three times during an assay.This publication has 1 reference indexed in Scilit:
- A simple method for the evaluation of local anaesthetic activity using earthwormsJournal of Pharmacy and Pharmacology, 1964