Specific IgE to food and inhalant allergens in intestinal washings of children affected by atopic eczema

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Abstract
Serum and rectal total and specific IgE were measured in 11 children with atopic dermatitis and 8 with atopic dermatitis and associated wheezing. Specific IgE to food and inhalant allergens in rectal washings were found in 14 patients. Of the 76 allergens which gave positive results, 20 were positive in both serum and intestine, 30 in serum alone and 26 in intestines alone. Specific intestinal IgE were confirmed by food challenge in 3 out of 4 patients whose skin-prick test and serum RAST [radioallergosorbent test] were both negative. Local production of these antibodies was demonstrated by the double ratio of Deuschl and Johansson and the specific activity ratio of Platts-Mills. Positive ratios (> 1) were obtained with both formulas for 12 of 14 allergens tested. Apparently, gut-associated lymphoid tissue may play a role in the pathogenesis of atopic disease.