Temporal Patterns of Silica Dust Exposure and Lung Dimensions in Relation To Silicosis

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Abstract
To determine whether certain temporal patterns of silica dust exposure, in addition to cumulative dose, and the dimensions of the lungs were related to elevated risk for silicosis, 168 silicotic cases were compared with 168 controls matched for cumulative dust exposure, year of birth and smoking. The data showed that the intensity of silica dust exposure was higher among cases when controlled for total cumulative dust exposure. Controls were found to have had significantly more time away from dust exposure during their mining careers. When cases and controls were compared for cumulative silica dust exposure and intensity of exposure for each decile of exposure time, the case-control differences were relatively constant throughout exposure time indicating that the timing of exposures was not an important risk factor. The height of the lungs was greater among cases compared with controls despite the fact that there were no differences in any of the other lung measurements or body length and after controlling for a significant difference in body mass index between cases and controls.

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