Local Resistance to a Lethal Dose of Formalin.

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Abstract
Increasing sublethal doses (4) of formalin given subcut. at the same site killed one of 34 mice; when given at 4 different sites the same procedures killed 25 of 28 mice. A lethal dose given at the site of 4 sublethal doses was resisted by 65 mice out of 74; given at a different site 7 survived of 61. Of 38 mice pretreated with formalin 36 survived a lethal dose of adrenalin when all injns. were given at the same site; when the adrenalin was administered at an unprepared site only 3 of 26 survived. Anatomical conditions observed at resistant sites provide a more reasonable interpretation of the resistance that was formerly accredited by Selye to the general "alarm reaction.".

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