The Message Is in the Translation
- 6 July 2001
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5527) , 60-62
- https://doi.org/10.1126/science.1062237
Abstract
It has been well established that cells control the activities of proteins by regulating their degradation. Now it seems cells also control protein activity by regulating when and where mRNAs encoding cellular proteins are translated. In their Perspective, Richter and Theurkauf examine how regulation of the translation of cyclin B and hunchback mRNAs controls cell proliferation and pattern formation in the developing fly embryo.This publication has 12 references indexed in Scilit:
- Biochemical Identification of Xenopus Pumilio as a Sequence-specific Cyclin B1 mRNA-binding Protein That Physically Interacts with a Nanos Homolog, Xcat-2, and a Cytoplasmic Polyadenylation Element-binding ProteinJournal of Biological Chemistry, 2001
- Drosophila Brain Tumor is a translational repressorGenes & Development, 2001
- Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation ComplexMolecular Cell, 2000
- CPEB, Maskin, and Cyclin B1 mRNA at the Mitotic ApparatusCell, 2000
- Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNANature, 2000
- Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4EMolecular Cell, 1999
- Recruitment of Nanos to hunchback mRNA by PumilioGenes & Development, 1999
- Maternal Pumilio acts together with Nanos in germline development in Drosophila embryosNature Cell Biology, 1999
- Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNADevelopment, 1997
- How Proteolysis Drives the Cell CycleScience, 1996