Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor
- 1 April 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 278 (5707) , 835-838
- https://doi.org/10.1038/278835a0
Abstract
An analog of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines [mouse 3T3 fibroblasts].This publication has 20 references indexed in Scilit:
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