CHROMOSOME-13 HOMOZYGOSITY IN OSTEOSARCOMA WITHOUT RETINOBLASTOMA
- 1 January 1986
- journal article
- research article
- Vol. 38 (1) , 59-66
Abstract
We provide evidence that some human osteosarcomas arise subsquent to the development of homozygosity at loci on the long arm of chromosome 13 The resulting chromsome 13q homozygosity allows the phenotypic expression of any recessive allele on that chromosome. Clinical evidence suggests that it is the retinoblastoma locus within 13q14 that is involved in the formation of these bone tumors.This publication has 25 references indexed in Scilit:
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