Steroids and Steroidases. XV. Investigations of Some 2-Lithio-1,3-dithiane Reactions Directed Towards the Introduction of Corticoid and Related Functions at C-17 of the Steroid Nucleus
- 1 May 1972
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 50 (9) , 1414-1420
- https://doi.org/10.1139/v72-220
Abstract
The potential of 2-lithio-1,3-dithiane reactions for the introduction of corticoid and related C-17 functions into the steroid nucleus has been explored. Although attempts to effect the direct addition of the dithiane reagents to C-17 ketones met with limited success, reactions of C-17 spiroepoxides were found to provide a convenient entry into routes to homocorticoid compounds.Keywords
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