Effect of 2‐diethylaminoethyl‐2,2‐diphenylvalerate hydrochloride (SKF 525‐A) on sulphacetamide distribution and excretion in rats

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Abstract
1 Administration of 2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride (SKF 525-A), 40 mg/kg, i.p., simultaneously or 40 min before sulphacetamide sodium, 100 mg/kg, i.p., was associated with a three-fold increase in sulphacetamide plasma concentration of rats. This effect was no longer evident after 30 minutes. 2 The augmentation in sulphacetamide plasma concentration was associated with parallel increases in the muscle, kidney and brain tissue. The stomach was the only organ that contained less sulphacetamide. 3 When sulphacetamide was administered i.v., a similar phenomenon was observed but the differences were less marked. 4 Pretreatment with SKF 525-A was associated with decreased excretion of sulphacetamide by the kidney. 5 It is concluded that SKF 525-A may alter the distribution and excretion of drugs as well as inhibiting drug metabolizing enzymes.